aroA [2017-07-27 10:39:06]

3-deoxy-D-arabino-heptulosonate 7-phosphate synthase / chorismate mutase-isozyme 3

locus: BSU29750

pI: 5.34

mw: 39.38 kDa

protein length: 358 aa

gene length: 1074 bp

function: biosynthesis of aromatic amino acids

product: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase /

essential: no

ec: 2.5.1.54

synonyms: aroG

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue]

Gene

Coordinates: 3,045,445 → 3,046,521

The protein

Catalyzed reaction/ biological activity

• Phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate (according to Swiss-Prot)

Protein family

• class-I DAHP synthetase family (according to Swiss-Prot)

Modification

• phosphorylation on Ser-2 [Pubmed|17218307]
• phosphorylation on Thr-4 [Pubmed|17726680]
• phosphorylated on Arg-45 and Arg-301 [Pubmed|22517742]
• Cys126 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|22938038]

Effectors of protein activity

• subject to feedback inhibition [Pubmed|19258532]

Structure

• [PDB|1VR6] (from ''Thermotoga maritima'', 51% identity, 68% similarity)

additional information

• belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

Expression and Regulation

Operons

• genes: [gene|75E331ABCDE1C60AAB4AC01229CED81B0AF50E1C|aroA]
  description: [Pubmed|9387221]

References

• 22938038,9387221,19258532,17726680,17218307,22517742,15378759,28743924